Data-based Extended Moving Horizon Estimation for MISO Anesthesia Dynamics

This paper presents an extended moving horizon observer to estimate both the states and pharmacodynamic (PD) parameters of anesthesia model, based on real data. The inputs this model are injection rates Propofol Remifentanil. represent concentration anesthetic agents in different compartments human body (muscles, fat, blood) effect site. considered output is Bispectral index (BIS) which derived from electroencephalogram (EEG). designed such that estimated during induction phase, then almost frozen for rest surgery. estimator validated data were extracted VitalDB database [12].